TBTU is an organic compound with a white to off-white crystalline powder appearance, a melting point of 205 ℃ and decomposition. It has relatively poor solubility in water, but is soluble in some organic solvents.
O-(Benzotriazol-l-yl)-N,N,N,N,-tetramethyluronium Tetrafluoroborate is an ideal solid-phase peptide synthesis coupling reagent. It is widely used in the field of peptide synthesis and can effectively promote the formation of peptide bonds and improve the efficiency and yield of peptide synthesis.


| CAS No. | 125700-67-6 |
| C11H164N5O | |
| 321.1 | |
| White to off-white powder | |
| 98% min. | |
| 200-205℃ (dec.) | |
| <=0.5% | |
| <=20 ppm |
TBTU, full name O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate, is a commonly used condensation reagent, which is widely used in organic synthesis and biochemistry. Its main uses include:
- widely used in solid or liquid phase peptide synthesis to promote the formation of amide bonds between amino acids.
- used for efficient condensation between carboxylic acids and amine compounds to improve reaction efficiency and yield.
- used to synthesize biologically active amides, peptide drugs and their intermediates.
- used as an efficient bonding reagent in research on protein and polymer modification.

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